![]() At molecular level, biliary excretion is dependent upon the molecular transporter MPR2 that is present on the cell canalicular membrane. ( 6, 7) After uptake by hepatocytes, Gd-EOB-dTPA is eliminated by biliary (50%) and urinary tracts (50%). The high contrast uptake is due to the lipophilic properties of Gd-EOB-dTPA, favoring its passive diffusion by molecular transporters OATP1, which are in the basolateral membrane of normal hepatocytes. In this stage, hepatocyte-free lesions (or lesions with dysfunctional hepatocytes) show low MRI signal intensity (dark images on a bright liver), with liver/lesion enhancement, improving the diagnostic capability of the test.ĭue to its hepatocyte specificity, the recommended dose of gadolinium is up to four times lower than that recommended for extracellular contrast media. After intravenous administration, Gd-EOB-dTPA is quickly distributed in the vascular/ interstitial compartment, allowing for a dynamic, multiphase study (arterial, portal and equilibrium phases).Īpproximately 50% of the injected dose of Gd-EOBdTPA is selectively captured by functioning hepatocytes and later excreted through bile, enabling acquisition of a late hepatobiliary phase, approximately 10-20 minutes after its injection. It was primarily developed to increase detection and characterization of focal hepatic lesions. Gd-EOB-dTPA is a liver-specific, gadolinium-based paramagnetic contrast, with combined properties of hepatocyte perfusion and selectivity. You will be screened to see how well your kidneys are working before you receive contrast.PHYSICAL CHEMICAL PROPERTIES AND BIOAVAILABILITY That causes severe thickening of the skin, muscles and other organs in the body. As a result, those people can develop a condition called nephrogenic systemic fibrosis. People whose kidneys don’t work well have trouble filtering the dye out of their bodies. Should I Avoid Getting Contrast?Ĭertain people should not have contrast or should use it in very limited amounts. Please call your doctor for medical advice about side effects. These are not all the possible side effects contrast. Your technologist will monitor you closely for symptoms of an allergic reaction during your exam. Sometimes, contrasts can cause serious allergic reactions. In addition, a small number of patients say that for a long time after their exam, they’ve:īut these symptoms have not been directly linked to contrast. ![]() Are There Side Effects?Ĭontrasts can cause side effects. If you or someone you care for is in one of these groups, please let your doctor know before your exam.
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